The Uptake of Lipoproteins by Ascites Tumor Cells
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چکیده
منابع مشابه
Uptake of Free Fatty Acids by Ehrlich Ascites Tumor Cells.
Plasma free fatty acid is the form in which fat is transported from the adipose tissue for utilization (2). Almost all of the FFAI present in plasma is tightly bound in a noncovalent complex with albumin, and less than 0.01 y0 is present unbound (i.e. in free solution) under ordinary conditions (3). However, in spite of the high association constants for binding of FFA to albumin, FFA leave the...
متن کاملUptake of partially thiolated DNA by ascites tumor cells.
The uptake and intracellular localization by Ehrlich ascites cells of partially [35S]thiolated homologous DNA ("antitemplate") were studied in comparison with that of the corresponding unmodified [3H]DNA, at 37 degrees and 0 degrees, under standardized conditions. For the unmodified DNA, washing the cells after incubation with 0.08 M iodoacetate (in 0.15 M NaCl) alone gave high but reproducible...
متن کاملSTUDIES ON PROTEIN UPTAKE BY ISOLATED TUMOR CELLS I. Electron Microscopic Evidence of Ferritin Uptake by Ehrlich Ascites Tumor Cells
Ferritin, added to the incubation medium of ascites tumor cells, was used as an electron microscopic marker to study the uptake of large protein molecules by morphologically intact cells. A definite uptake could be detected after I hour of incubation in Tyrode bicarbonate solution containing 0.04 to 13.3 mg ferritin/ml. Ferritin was found in a variety of membrane-surrounded structures, suggesti...
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Background: Dendritic cells (DCs) are professional antigen presenting cells (APCs), and there is considerable interest in their application as a cellular adjuvant for cancer immunotherapy. Previous studies indirectly demonstrated that DCs were able to take up tumor lysate (crude soluble tumor antigens) and also cross-present tumor associated antigens (TAA) which elicits anti-tumor immune respo...
متن کاملUptake of ribopolynucleotides by mammalian cells. 13. DNA, a component of the outer membrane of Ehrlich ascites tumor cells and its role in RNA uptake by these cells.
DNase treatment of Ehrlich ascites tumor cells releases DNA fragments from the membrane surface. This increases the capacity of the cells for homoribopolynucleotide uptake. Another portion of membrane DNA is embedded in protein structures and is not accessible for DNase. This DNA does not hinder ribopolynucleotide uptake unless it is unwrapped by a sub sequent pronase treatment of the cells. W...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1958
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)68034-8